Of particular interest was Homer's encounter with a Native woman, who finds him after he wanders off into the Alaskan wilderness. She takes him home and revives him with a fiery brew. Then she guides him to his preordained destiny: to return to Springfield and save the day.
The scene includes some good and not-so-good bits of Inuit and Native Alaskan cultures. Since the woman doesn't identify herself or her ethnicity, she may belong to one or both cultures. Perhaps she's consciously mixing the cultures.
The details [stop reading if you don't want to spoil the scene]:
In reality, throat-singing is a kind of vocal game with no metaphysical significance. On the other hand, blowing magic smoke on Homer or feeding him a magic stew might've been stereotypical.
Since she's not a nubile young thing, her voluptuousness doesn't seem especially gratuitous. But it's an example of The Simpsons' disdain for female characters. Other than the Simpsons family, the show's only noteworthy women are the man-hungry Patty and Selma and Mrs. Krabappel.
The Simpsons team could've mixed the Inuit and Native Alaskan bits intentionally to make a point about cultural synthesis. More likely, though, they did it heedlessly--using everything they could think of to create a pan-Alaskan sense of "Nativeness." It would've been better to make the medicine woman Inuit or Native Alaskan, since they aren't the same thing.
At least they didn't stick her in an igloo or have her act "primitively." The hut and its artwork convey a certain sense of sophistication. If she's a traditional Native who lives alone for some reason, her life looks comfortable and secure.
As I said, the scene is something of a mishmash. The show previously evinced some sensitivity to Native concerns, and the movie continues this hit-and-miss sensitivity. It could be a little better, but it also could be much worse.
Below: The medicine woman's concoction revives Homer.