Wikipedia gives us the movie's plot:
Rachel and Timothy have been unaware that the rest of the family are "good" werewolves that have guarded Timothy and his secret since birth. They know that Timothy is a half blood, and will control the destiny of the family. But they also know that Timothy's power will put him in danger, for there are other werewolves that revel and embrace their blood-lust that are prepared to kill to preserve their way of life. These werewolves, led by Varek (Behr), Zo (Coates) and Sonya (Malthe), are hell bent on finding Timothy; their kin.
Boo Boo: I am from Arizona and a Navajo, i have never heard of the tale of the pale people before... But the real story of the skinwalkers is evil medicine men or women who want to gain more power or whatever they want, go through a ceremony that lasts for days.Through that ceremony they transform into a coyote or a dog, in order to go on their travel. also it can be anyone, not just medicine men or women. it was created back then during the wars between tribes, in order to travel fast in long distances. when they travel they are in dog form, but when they need to do their job, they are in skinwalker (yanogloshi) form, some say it looks as if skin is in the shape of a human body with red eyes. they only travel at night, where no one can see them (they are incognito, as you can say). that's why the elders say you shouldn't be outside at night, plus you have no business being out there in the first place.
feelion: From what I've seen on this website the movie is loosely based on the Navajo legend of skinwalkers. However, it appears more to be based on a cross between skinwalker legend and vampire and werewolf media.
On the subject of skinwalkers, BOO BOO has the best input I've seen thus far. I'm not Navajo but I do study a lot of mythology. Her point that these are evil witches who become skinwalkers, by choice, is a very important distinction between the real Navajo legend and this movie. There is actually more to it, but my resources are second hand accounts and the internet, neither of which of which would garner much respect for accuracy. The lack of reliable sources is also due to younger generations of Native Americans choosing to ignore the cultural history that their parents and/or grandparents have to offer (in preference to conforming to mainstream America...sort of), or lost much of their heritage due to the U.S. government intervening in tribal affairs to "Americanize" the Native Americans (what laughable idea that was). And to speak of such a topic outside of the tribe, outside of shelter, and/or at night is supposedly considered taboo.
navijowalker: Skin-walker (mythology).
Also, I'll be curious the movie offers anything we didn't see in Wolf Lake, the underrated TV series from a few years ago. Good vs. bad werewolves, werewolves struggling with the change at puberty...it's been done before.