Some Native American peoples regarded horned lizards as sacred. The animal is a common motif in the art of many Native Americans in the Southwestern U.S. (namely, Navajo) and in Mexico. In the Clint Eastwood film The Outlaw Josey Wales, the character played by Chief Dan George decides to go to Mexico based on signs given to him by a horned toad.
The horned lizard is the state reptile of both Texas and Wyoming, and the horned frog is the mascot of Texas Christian University (TCU).
The legend of Ol' Rip, a horned toad (allegedly) discovered alive in the cornerstone of a demolished courthouse in Eastland, Texas in 1928, has been well-publicized. A horned toad had been placed there in 1897 as part of a time capsule.
The story of Ol' Rip is thought by some to have inspired the Looney Tunes short One Froggy Evening. Presumably, creator Michael Maltese, being from outside the lizard's range, either took the amphibian nomenclature literally, or just went with it because it made a better story.