Here's Elijah DeJesus playing an unpopular Latina girl in Ugly Betty. (I saw this episode and it was good.)
Here are some photos of DeJesus as Pearl Carter Scott and the real Pearl.
According to this posting, Pearl's mother was half Chickasaw and half Choctaw. Her father was non-Native.
Since Pearl was only part Indian by blood, I guess it's okay for a Latina to play her. But it's a shame that only two Chickasaw citizens were cast among the 22 biggest speaking roles. (Another six Chickasaw citizens got minor roles--essentially extras.) And it would be a shame if her relatives or neighbors were mostly black and the movie changed them to white.
For more on the subject, see The Best Indian Movies.