During the meeting behind closed doors, the Pope is expected to read a statement about the Roman Catholic Church's role in the residential school system in Canada.
The church administered three-quarters of residential schools across Canada, but has yet to apologize for the abuse suffered by many of the 90,000 former students still alive.
Assembly of First Nations Leader Phil Fontaine is part of the delegation, which also includes elders and survivors.
"We're going to be in conversation with the Holy Father, and we're going to talk about the residential school experience," he told CBC News.
Isabella Tatar, head of the Legacy of Hope Foundation, which seeks to create awareness about the effects of residential schools, said the meeting represents an important step forward.
"The fact that survivors, their experiences are being validated, I think that will serve a very effective tool or forum for closure, not necessarily for everyone, but I think for a significant number of people," she said.
Note that the survivors already have a financial settlement, which Fontaine called a "symbolic apology," and an actual apology from Canada's prime minister. They've also asked the Queen of England to apologize.
One has to wonder why these apologies haven't provided "closure" yet and which apology will be the final apology needed. If the Pope apologizes and that doesn't do the trick, then what?