As you'll recall, the books feature Quileute Indians as werewolves. Here's the scoop (from Savage Indians):
Indians received not only similar descriptions to those given predatory animals, but much the same treatment as well. George Washington, revered as the father of the country, wrote that Indians "...were wolves and beasts who deserved nothing from the whites but 'total ruin'" (Stannard, p. 241). Thomas Jefferson, acclaimed proponent of freedom and democracy, argued that the United States government was obliged "...to pursue [Indians] to extermination, or drive them to new seats beyond our reach" (quoted in Takaki, 1979, p. 103). Andrew Jackson, founder of the modern Democratic Party and greatest Indian killer of all American Presidents, urged United States troops "...to root out from their 'dens' and kill Indian women and their 'whelps'" (Stannard, p. 240).
For more on the subject, see Quileute Werewolves in Twilight.
Below: Three big Twilight fans. "Indians as human wolves...perfect!" says Washington. "Two claws way up!" says Jefferson. "I love that whelp Jacob so much I could hug him to death!" says Jackson.